Alpine Loop Back Country Byway is in southwest Colorado about 100 miles southeast of Grand Junction. The byway forms a loop drive between Lake City and the towns of Ouray and Silverton. Alpine Loop is 65 miles long and is generally open late June through October.

Flat Tops Trail is in northwest Colorado about 100 miles northeast of Grand Junction. It crosses the White River and Routt National Forests between Meeker and Yampa. The byway follows CR 8 and FSR 16 over a combination of paved and gravel-surfaced roads. Most vehicles are able to complete the entire 82-mile route. Flat Tops Trail receives two to ten feet of snow in winter and is not maintained for automobile use. It is open for snowmobile and cross-country ski use.

Frontier Pathways is in south-central Colorado near Pueblo. The byway follows CO 96 between Pueblo and Westcliffe and CO 165 between Colorado City and Rockvale. Both state highways are two-lane paved roads suitable for all types of vehicles. Portions of the 103-mile byway may close in winter, otherwise it usually remains open year-round.

Gold Belt Tour is in central Colorado about one hour's drive from either Colorado Springs or Pueblo. The byway follows a series of roads between Cripple Creek and Canon City. From Colorado Springs, the byway is reached by following US 24 west to CO 67, then south to Cripple Creek. The southern end of the byway is off US 50, about 50 miles west of Pueblo.

Grand Mesa is 22 miles east of Grand Junction in west-central Colorado. The byway follows CO 65 and Lands End Road (FSR 100). Travelers can access the byway from I-70 at Exit 49 or in the town of Cedaredge. Colorado Highway 65 is a two-lane paved road that is suitable for all vehicles. Lands End Road is a maintained gravel road that is closed in winter. Although most passenger cars and RVs can complete this portion of the byway, it is best to inquire locally about current road conditions. Colorado Highway 65 is usually open year-round.

Guanella Pass is in central Colorado, 45 miles west of Denver. The byway's northern access is in Georgetown and its southern in Grant. It is 22 miles long and follows Guanella Pass Road. The first ten miles from Georgetown is paved; the remaining is gravel. Large RVs or vehicles pulling trailers are not recommended on the byway. Guanella Pass is usually maintained year-round except for days following heavy snow. Caution should be exercised if traveling the byway in winter.

Highway of Legends is in southern Colorado about 50 miles south of Pueblo. The byway forms an open loop beginning in Walsenburg and ending in Trinidad. It follows US 160 and CO 12 for 82 miles. Both highways are two-lane paved roads suitable for all types of vehicles. The highways are usually open all year.

Los Caminos Antiguos is in south-central Colorado about 120 miles southwest of Pueblo. The byway begins in Alamosa, travels by the Great Sand Dunes National Monument, and then heads south to end at the New Mexico state line. It follows CO 17, CO 142, CO 150, CO 159, US 160, and US 285. A short segment also follows Six Mile Lane between CO 17 and CO 150. All the roads are two-lane paved roads suitable for all types of vehicles. The byway is 152 miles long and is usually open year-round.

Mount Evans is approximately 30 miles west of Denver in central Colorado. It begins near Idaho Springs and travels south through Arapaho National Forest to the summit of Mount Evans. The byway follows CO 103 and CO 5, which are two-lane paved roads. Colorado Highway 103 is suitable for most vehicles including those pulling trailers 25 feet long or less. Colorado Highway 5 is not recommended for large RVs or vehicles pulling trailers. The byway is 28 miles long. Highway 5 is usually open Memorial Day through Labor Day.

Peak to Peak is in north-central Colorado about 30 miles west of Denver. The byway's northern terminus is in Estes Park. It travels south through Roosevelt National Forest and ends at the junction with US 6. The byway follows CO 7, CO 72, and CO 119; all are two-lane paved roads suitable for all types of vehicles. Peak to Peak is 60 miles long and usually remains open year-round. Delays are possible during winter for snow removal.