Also see Alabama and Tennessee

This historic route generally follows the old Indian trace, or trail, between Nashville, Tennessee and Natchez, Mississippi. This is the longest portion of the parkway as it crosses Mississippi from Natchez to the Alabama state line, a distance of 310 miles. The parkway is a two-lane paved road suitable for all types of vehicles and remains open year-round. A small 17-mile portion running through Tombigbee National Forest is officially designated a National Forest Scenic Byway.