Blue Buck Knob is in south-central Missouri about 75 miles east of Springfield. It begins in Cabool and travels south through the Mark Twain National Forest to the intersection with MO 14. The byway is nearly 30 miles long and follows Missouri Highways 76, 181, and "AP." The state highways are two-lane paved roads suitable for all vehicles. Blue Buck Knob generally remains open year-round.

Glade Top Trail is in southwest Missouri about 55 miles southeast of Springfield. To reach the northern terminus from Ava, follow MO 5 south to MO "A." Follow MO "A" to CR 409 and take CR 409 to the national forest entrance, where the byway officially begins. Glade Top Trail is 23 miles long and follows FSR 147 and FSR 149, which are two-lane gravel roads suitable for most vehicles. The roads usually remain open year-round; caution is needed during winter.