Covered Bridge scenic byway is in southeast Ohio east of Marietta. The byway begins at the junction of OH 7 and OH 26. It follows OH 26 northeasterly to Woodsfield. The highway is a narrow, two-lane paved road suitable for most vehicles. Covered Bridge is 47 miles long and is open all year.

Ohio River Scenic Route crosses southern Ohio for 452 miles. It primarily follows US 50, US 52, and OH 7 from the Indiana state line to the Pennsylvania state line. The roads are primarily two-lane paved roads suitable for all vehicles. In eastern Ohio, OH 7 is a four-lane divided highway. Ohio River Scenic Route is generally open year-round.

Ohio River Scenic Route cuts across southern Ohio through hardwood forests and rocky hillsides. It travels through numerous historical towns and sites. In Steubenville is the restored Fort Steuben, a 1780s fort built under the command of Captain John Francis Hamtramck to protect the early land surveyors. The birthplace of Ulysses S. Grant is along the byway in Point Pleasant near Neville. The site contains a restored three-room cottage where the 18th President of the United States was born.