Beartooth Highway is in northwest Wyoming and southern Montana. It begins in Red Lodge, Montana and travels southwest to Yellowstone National Park. The byway follows US 212 for 68 miles. US Highway 212 is a two-lane paved road suitable for all vehicles. Beartooth Highway is usually open late May through mid-October. Portions of the route are groomed in winter for snowmobile use.

Bighorn scenic byway is in north-central Wyoming 21 miles west of Sheridan. It follows US 14 between Dayton and Shell, a distance of 58 miles. US Highway 14 is a two-lane paved road suitable for all vehicles. Temporary closure by snow is possible in winter, otherwise the byway remains open year-round. Forty miles are officially designated a National Forest Scenic Byway.

Cloud Peak Skyway is 35 miles south of Sheridan in north-central Wyoming. It begins in Buffalo and travels west to Ten Sleep. The byway is 67 miles long and follows US 16, a two-lane paved road suitable for all vehicles. Temporary closure by snow is possible in winter, otherwise the byway is open all year. Wyoming has officially designated 47 miles as a state scenic byway. The US Forest Service designated 43 miles as a National Forest Scenic Byway.

John D. Rockefeller, Jr. Memorial Parkway is in northwest Wyoming. It follows US 89 between Grant Village and Moose, a distance of 82 miles. US Highway 89 is a two-lane paved road suitable for all vehicles. The highway north of Flagg Ranch is not maintained during winter; access to Yellowstone National Park is by snowmobile or commercial snow coach. The portion from Moran Junction to Moose is also part of the Wyoming Centennial byway.

Medicine Wheel Passage is 47 miles west of Sheridan in north-central Wyoming. It follows a 27-mile segment of US 14A, a two-lane paved road suitable for all vehicles. Medicine Wheel Passage is usually open May to mid-November.